The British team of Cash and Patten were defeated 6-4, 6-7(5), 7-6(10-6) by the sixth-seeded Indo-Australian combination at the Arthur Ashe Stadium on Sunday after a gruelling two hours and 22 minutes of play. Bopanna and Ebden, who advanced to the Wimbledon quarterfinals earlier this year, racked up 13 aces and won 81% of their first-serve points.

The victors of the third-round match between top seeds Wesley Koolhof of the Netherlands, Neal Skupski of the United Kingdom, and the local team of Nathaniel Lammons and Jackson Withrow will then take against the losers. Yuki Bhambri and Saketh Myneni were eliminated in the first round of the men's doubles competition, leaving the 43-year-old as the lone Indian still in the running.